Sequence 1
Boys Will Be Boys
Fight Vieri de Pazzi's Men
If you're going to be an assassin, you're going to have to fight like one. For now, you'll have to fight two waves of Vieri de Pazzi's men. Thankfully, the game will walk you through the control basics. Basically, you'll want to lock-on to an opponent before you start throwing punches. Once you have, you can perform combo attacks by tapping the attack button immediately after each attack connects--keep it up to string several attacks together, forming a combo. These are both faster and more effective than stand-alone punches, so practice your timing! In addition, if you're surrounded by several enemies, try grabbing one and tossing him into others to knock them back. Vieri de Pazzi's men will retreat before long.
Loot 200 Florins to Pay the Doctor
After Vieri de Pazzi's men retreat, loot the fallen bodies by standing over them and pressing the button shown on-screen. After collecting enough money, the mission will end.
You Should See the Other Guy
Follow Federico to the Doctor
Federico will lead you right to the doctor, but it's important you keep up as he scampers up buildings and the like. To do so, you'll have to enter "free run" mode, which enables you to climb structures and buildings with ease. Just hold down the required buttons and keep on Federico's tail--he'll take you right to the doctor.
Sibling Rivalry
Win the Race Against Federico
It's a race between you and Federico! Luckily, he's kind of slow--as long as you trail him closely for the first portion, you should be able to edge him out before leaping to the church's rooftop. Start off by racing up the nearby boxes and across the poles. You'll soon find a suspended platform you can jump across to another roof--from there, jump to the church and clamber up to its top for the finish!
After winning, follow your friend up the nearby tower. Again, use "free run" mode to climb it, though you may have to sidle around around to either side once or twice in order to find more grip-points, enabling you to continue your ascension.
Nightcap
Pay a Surprise Visit to the Beautiful Cristina Vespucci
From the tower, step out onto the wooden beam to find the first of many Viewpoints. Each time you find one, it fills in the nearby area on your map, including the locations of other nearby viewpoints--you'll find them scattered all over each area. It's important you find these whenever possible in order to make your map usable.
After synchronizing with the viewpoint, take a Leap of Faith into the hay stack below. As you'll soon discover, hay stacks, in addition to wells and rooftop hutches, can conceal you from the prying eyes of your enemies, so use them to stay out of sight. In this case, after the scouts pass by, head for the area marked on your mini-map, just up the street. After speaking with Cristina through the window, climb up to her using the windows below as grapple-points.
Escape the Guards
To escape the guards, quickly free-run up a nearby building then skip along the rooftops until you've lost them.
Paperboy
Deliver Giovanni's Letter to Lorenzo de' Medici
The easiest and quickest way to Lorenzo's place is to scale the nearby building first, then cross over the rooftops to his general location, before dropping back down to street level to find. This way, you won't draw any attention from the guards at all.
Return to Giovanni
After delivering the letter, use the same tactics to return to Giovanni. That is, scale the building then cross over the roofs to avoid the guards. Knock on Giovanni's door once you've arrived.
Beat a Cheat
Find and Punish Duccio
Cross over the rooftops to find the guards toward Duccio's location, as marked on your mini-map. Once you find him, rough him a bit with some punches, and throw some grab attacks in there for good measure too. He's weak, so he'll go down pretty quick.
Petruccio's Secret
Obtain Eagle Features for Petuccio Before He Gets in Trouble
You have two and a half minutes to gather the three features marked on your map. Luckily, that's plenty of time. Climb up the rooftop behind you for the first one, then cross over the nearby roofs to a large, curving rooftop where you'll find the other two. Once you've gathered all three, return to Petuccio's house and knock on his door to deliver them--you're not timed during this segment, so take as long as you need.
Friend of the Family
Follow Maria
Stay close to Maria as she leads you to your destination. As long as you don't run around, shove people, or pick their pockets, this should be an uneventful journey.
Carry the Box to Palazzo Auditore
Grab the box from the ground (by standing in front of it and pressing "Grab"--it may take a few tries, as the game's pretty finicky) and then follow the streets toward the destination marked on your map. Drop the box there to complete the mission.
Special Delivery
Deliver Two Letters and Retrieve a Third from the Pigeon Coop for Giovanni.
Three tasks, three marks on your map. Stick to the rooftops as you journey from one to the next to evade the guards. We suggest heading for the one to the south first and working your way from there. Doing so, you'll deliver the two letters first (the first on ground level, the second on a low roof), before finding the bird atop a building. You'll finish the mission upon completing all three.
Jailbird
Climb the Palazzo Tower to Giovanni's Cell
Use the rooftops to reach the jail on which the tower resides, so as to not alert the guards to your presence. We suggest climbing it via the north side to the lower level's rooftop where you'll spot a lone archer. Take him out (either bu punching him, or throwing him off the building), then climb up a few ladders to the higher level. There you'll find one more archer as well as the tower. Take out the archer using the same methods, then climb up the tower's face side as high as you can, then sidle to the left side to continue your ascent to the window, where you'll complete the mission.
Family Heirloom
Find the Hidden Room and Retrieve the Chest's Contents
From the get-go, activate your Eagle Vision (by holding "Y" on 360, or "Triangle" on PS3) to spot a hidden door dead-ahead you can open. Open the chest inside to find the assassin's uniform. Now exit back outside.
Deliver the Documents to Uberto Alberti
As you step outside, two guards will attack. You can either kill them, or simply run away toward the marked destination. If you choose to battle them, countering's the easiest method in which to dispatch them. To counter, simply hold block, then tap "attack" as soon as you spot one of them attacking. Once they're dealt with, use the rooftops to reach your destination--just be ready for a couple more guards waiting for you there.
Last Man Standing
Attend the Acquittal
Head up the street to find the acquittal, as marked on your map.
Escape the Guards
After the execution, you'll have to ditch the guards by running away. Simply dart for a side-street and onto a rooftop as soon as you can--use your mini-map to keep an eye on the guards' locations, as well as potential hiding spots (the blue dots) you can duck into, such as hay stacks or rooftop hutches. If you're discovered, simply take off for another hiding spot--you'll finish the mission as soon as you lose 'em.